Averaging Level Control to Reduce Off-Spec Material in a Continuous Pharmaceutical Pilot Plant
نویسندگان
چکیده
منابع مشابه
Averaging Level Control to Reduce Off-Spec Material in a Continuous Pharmaceutical Pilot Plant
The judicious use of buffering capacity is important in the development of future continuous pharmaceutical manufacturing processes. The potential benefits are investigated of using optimal-averaging level control for tanks that have buffering capacity for a section of a continuous pharmaceutical pilot plant involving two crystallizers, a combined filtration and washing stage and a buffer tank....
متن کاملRobust Averaging Level Control
Frequent inlet flow changes typically cause problems for averaging level controllers. For a frequently changing inlet flow the upsets do not occur when the system is in steady state and the tank level at its set-point. For this reason the tuning of the level controller gets quite complicated, since not only the size of the upsets but also the time in between them relative to the hold up of the ...
متن کاملModel-Based Design of a Plant-Wide Control Strategy for a Continuous Pharmaceutical Plant
The design of an effective plant-wide control strategy is a key challenge for the development of future continuous pharmaceutical processes. This article presents a case study for the design of a plant-wide control structure for a system inspired by an end-to-end continuous pharmaceutical pilot plant. A hierarchical decomposition strategy is used to classify control objectives. A plant-wide dyn...
متن کاملLocal averaging and differentiating of spec
Local frequency and time averaging and differentiating operators, using three neighboring points of critical-band timefrequency plane, are used to process the plane prior to its use in TRAP-based ASR. In that way, five alternative TRAP-based ASR systems (the original one and the time/frequency integrated/differentiated ones)are created. We show that the frequency differentiating operator improv...
متن کاملFailure of Intravenous Lipid Emulsion to Reduce Diazinon-induced Acute Toxicity: a Pilot Study in Rats
Diazinon (DZN) is a synthetic organophosphorus (OPs) insecticide widely used in agricultural and household applications. OPs, particularly DZN, are highly lipid soluble liquids. Intravenous lipid emulsion (ILE) has been shown to reduce toxicity caused by some lipid soluble agents. We evaluated the antidote effect of ILE on acute toxicity of DZN. Twenty-four Sprague-Dawley female rats weightin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Processes
سال: 2013
ISSN: 2227-9717
DOI: 10.3390/pr1030330